IgG Antibodies Generation and Side Effects Caused by Ad5-nCoV Vaccine (CanSino Biologics) and BNT162b2 Vaccine (Pfizer/BioNTech) among Mexican Population

SARS-CoV-2 has rapidly generated a pandemic. Vaccines are currently being rolled out to control the viral spread and prevent deaths. Emergency vaccines, using new platforms, have been approved. Their effectiveness, safety immunogenicity in different populations not fully known. This study aimed discover of messenger ribonucleic acid (mRNA) BNT162b2 adenovirus vector Ad5-nCoV vaccines through IgG antibody generation against subunit 1 protein S (S1 IgG) assess side effects vaccines. A total 115 vaccinated people were included, 61 whom received vaccine, while 54 Ad5-nCoV. Measurements S1 antibodies carried enzyme-linked immunosorbent assay (ELISA) technique. The vaccine 80.3% participants after first dose. number seropositive increased 98.36% with administration second 88.89% those vaccinated. Women more when administered either vaccine. There no serious adverse from vaccination. In conclusion, all had detectable antibodies. presented most seronegative cases. studied shown be safe.